Second-generation antipsychotic use during pregnancy and risk of congenital malformations

Duration of antidepressant use during pregnancy and risk of major congenital malformations.

BACKGROUND Antidepressant use during the gestational period is a controversial topic. AIMS To determine whether duration of antidepressant use during the first trimester increases the risk of major congenital malformations in offspring of women diagnosed with psychiatric disorders. METHOD A case-control study was performed among women who had been pregnant between January 1998 and December ...

Use of selective serotonin-reuptake inhibitors during early pregnancy and risk of congenital malformations: updated analysis

BACKGROUND Data on the safety of selective serotonin-reuptake inhibitors (SSRIs) in pregnancy are inconsistent. We examined associations between SSRI use during early pregnancy and risk of congenital malformations in infants. METHODS Set in Northern Denmark, our population-based prevalence study included 216,042 women who had a live birth after the 20th week of gestation. We compared the prev...

Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents.

CONTEXT Cardiometabolic effects of second-generation antipsychotic medications are concerning but have not been sufficiently studied in pediatric and adolescent patients naive to antipsychotic medication. OBJECTIVE To study the association of second-generation antipsychotic medications with body composition and metabolic parameters in patients without prior antipsychotic medication exposure. ...

Atypical antipsychotic use during the first trimester of pregnancy may not increase major malformations.

McKenna K, Koren G, Tetelbaum M, et al. Pregnancy outcome of women using atypical antipsychotic drugs: A prospective comparative study. J Clin Psychiatry 2005;66:444–9. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Organic solvent exposure during pregnancy and congenital malformations.